Innovative Development of Androgen-Metabolizing Probiotics: Functional Gut Microbiome Therapy for Hyperandrogenism Treatment
Technology Introduction:
Our team discovered that probiotic Bacillus coagulans specifically metabolizes dihydrotestosterone, treating hyperandrogenism-related diseases like androgenic alopecia, prostate disorders, and polycystic ovary syndrome (PCOS). Mouse studies confirmed significant serum dihydrotestosterone reduction and hair loss prevention. We are developing functional gut bacteria through interdisciplinary microbiota-hormone research to address excessive androgen levels regulated by enterohepatic circulation.
Industry Applicability:
We isolated Bacillus coagulans that specifically metabolize dihydrotestosterone, effectively reducing serum androgen equivalent. This technology creates new therapeutic pathways for hyperandrogenism conditions. Industrial applications include: (1) functional probiotic health foods for Taiwan's health market; (2) therapeutic microbial preparations; (3) postbiotic natural product development. We have completed patent applications and signed technology transfer agreements with 2 domestic companies.
Our team discovered that probiotic Bacillus coagulans specifically metabolizes dihydrotestosterone, treating hyperandrogenism-related diseases like androgenic alopecia, prostate disorders, and polycystic ovary syndrome (PCOS). Mouse studies confirmed significant serum dihydrotestosterone reduction and hair loss prevention. We are developing functional gut bacteria through interdisciplinary microbiota-hormone research to address excessive androgen levels regulated by enterohepatic circulation.
Industry Applicability:
We isolated Bacillus coagulans that specifically metabolize dihydrotestosterone, effectively reducing serum androgen equivalent. This technology creates new therapeutic pathways for hyperandrogenism conditions. Industrial applications include: (1) functional probiotic health foods for Taiwan's health market; (2) therapeutic microbial preparations; (3) postbiotic natural product development. We have completed patent applications and signed technology transfer agreements with 2 domestic companies.
Industrial Applications:
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Academia Sinica
Founded in 1928, Academia Sinica has earned a reputation for being Taiwan’s national academic institution. Our statutory mission is to pursue research excellence, nurture academic talent, and issue policy advisories.
Academia Sinica currently has 24 institutes and 9 research centers located in three research sections: the Mathematics and Physical Sciences Division, Life Sciences Division, and Division of Humanities and Social Sciences. There are currently over 8,000 research fellows, research technicians, assistants, and administrative staff, making it a rare research institution internationally that achieves a balanced development in both natural sciences and humanities and social sciences.
Academia Sinica currently has 24 institutes and 9 research centers located in three research sections: the Mathematics and Physical Sciences Division, Life Sciences Division, and Division of Humanities and Social Sciences. There are currently over 8,000 research fellows, research technicians, assistants, and administrative staff, making it a rare research institution internationally that achieves a balanced development in both natural sciences and humanities and social sciences.
Contact Information
Name：-
Tel：02-2787-2251
Address：No. 128, Sec. 2, Academia Rd., Nangang Dist., Taipei City 115201 , Taiwan (R.O.C.)
Additional Information
Pavilion：Future Tech Bio-tech, New Drugs & Medical Devices FM05
Exhibiting Entity：National Science and Technology Council
Application Category：Biotechnology and Medicine
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Pavilion：Future Tech Bio-tech, New Drugs & Medical Devices FM05
Exhibiting Entity：National Science and Technology Council
Application Category：Biotechnology and Medicine
