Bacillus amyloliquefaciens YCMA1, a strain isolated from mud volcano mud, exhibits high tolerance to over 40 pesticides (including insecticides, fungicides, and herbicides) and can be effectively combined with them. It demonstrates potent antagonistic activity against a wide range of plant pathogenic fungi and bacteria, having successfully completed 15 antifungal and 7 antibacterial activity tests. This strain holds significant promise for the development of a broad-spectrum biopesticide.