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Our team has developed a rapid microfluidic paper-based chip detection system that utilizes smart networking technology to upload results to the cloud for management and analysis. The system establishes predictive models to generate personalized reports, providing doctors and patients with immediate and accurate assessments and recommendations, achieving the goal of home testing. Through this innovative system, we aim to provide better health management tools for chronic kidney disease patients.
Future Tech | Biotechnology ＆ Medical careStroke leads to death and disability, traditional rehabilitation is limited by poor cardiopulmonary function. A comprehensive rehabilitation system combining brain-machine interfaces, real-time physiological monitoring, exoskeletons, and dynamic reduced-weight walking can enhance cardiopulmonary function, promote active participation, and accelerate recovery. Real-time monitoring ensures safety, improves brain function, enhances rehabilitation outcomes, and reduces family and social burdens.
Future Tech | Biotechnology ＆ Medical careOur technology detects biological targets, including bacteria, proteins, and exosomes, in micro-volume samples rapidly and quantitatively. By conjugating Janus particles with antibodies, biological targets can be captured, thus changing the diameter and slowing diffusion. Rotational Brownian motion is quantified by antibody-conjugated Janus particles based on the Stokes-Einstein-Debye relation, where rotational diffusion is mainly inversely proportional to the particle diameter cubed.
Future Tech | Biotechnology ＆ Medical careThis study employs Interfacial Polyelectrolyte Complexation Spinning (IPC) technology to fabricate tissue-engineered ligaments. By combining our customized machinery with gradient mineralization process, we create artificial ligaments replicating the physiological properties of natural ligaments. The technology includes the incorporation of biomolecules and cell therapies, enabling regenerative potential and improving clinical outcomes by providing effective, durable ligament repair options.
Future Tech | Biotechnology ＆ Medical careWe aim to construct in vitro multi-organ models (e.g., liver/kidney or liver/kidney/tumor), and to simulate the micro-environments interaction by using the "multi-organ array composed of assemblable organ chip bricks". It can be applied to drug metabolism, safety, and toxicity testing related to liver and kidney organs, as well as new drugs development in animal experiments. Therefore, it is expected to reduce animal expenditure in the drug development by over 50%.
Future Tech | Biotechnology ＆ Medical careThis technology uses the pTCY plasmid to carry the antigen gene, and combines with peptide nanotubes to make a nanocarrier vaccine. The advantages include high surface area, long residence time, low toxicity, etc. It is the best delivery system for antigens and drugs. We used software to analyze the structural proteins with the best antigenicity of pathogens and constructed effective gene fragments into expressed DNA plasmids. This technology platform can be applied to various mucosal diseases.
Future Tech | Biotechnology ＆ Medical careUsing high-throughput screening, we discovered that soybean isoflavone genistein (GEN) is a novel CB1 receptor antagonist that does not cross the blood-brain barrier, thereby avoiding CNS effects and psychiatric side effects. We further enhanced the water solubility and oral bioavailability of GEN through microbial fermentation. This strategy has been patented and can be used to treat cardiovascular diseases and has therapeutic potential for other diseases related to abnormal CB1 activation.
Future Tech | Biotechnology ＆ Medical careThis technology＇s theoretical foundation lies in using small molecules to reprogram human fibroblast cells into retinal progenitor cells (CiRPC), making it the world＇s first chemically reprogrammed human retinal progenitor cell for clinical use. It regulates gene expression via specific signaling pathways to induce trans-differentiation, based on stem cell biology principles. This method avoids genetic modification and viral vectors, reducing potential safety risks. Our technology boasts the following key features and innovations: 1. Low mitotic retinal progenitor cells with no risk of teratoma formation or tumorigenicity: By utilizing these progenitor cells, we reduce the risk of adverse reactions such as teratoma or cancer formation during treatment, thereby enhancing the safety and reliability of therapy. 2. Precise cell reprogramming technology: We possess precise cell reprogramming technology capable of converting human fibroblast cells into retinal progenitor-like cells, addressing patients＇ photoreceptor degeneration issues, and enhancing their visual recovery. 3. High efficiency and low-cost reprogramming process: Our technology achieves a conversion efficiency of up to 42.8%, with a reprogramming time of just 5 days, and utilizes small molecules as reprogramming factors, reducing the cost of cell processes and potentially alleviating the economic burden on patients. 4. No genetic modification or viral intervention: Our cell reprogramming process does not require genetic modification and avoids viral intervention, thereby enhancing the safety and reliability of treatment. 5. Unique color visual recovery experience: The technology can differentiate into black-and-white sensitive rod cells and cone cells capable of receiving color visual signals. Through subretinal injection, induced retinal progenitor cells will provide patients with a more diverse vision recovery experience.
Future Tech | Biotechnology ＆ Medical careThe biofilm formed by bacteria is the main cause of Catheter-Associated Urinary Tract Infections (CAUTIs). Currently, there is a lack of safe and effective strategies for biofilm removal in clinical settings. Our invention, ERAfilm, can remove nearly 95% of the biofilm on catheters removed from CAUTI patients within 10 minutes. It is non-toxic to human bladder cells and does not induce bacterial resistance. ERAfilm holds promise as an important solution for preventing CAUTIs.
Future Tech | Biotechnology ＆ Medical careHearing aids are vital tools for individuals with hearing impairment, yet they face challenges in noisy environments and during distant conversation conditions. This project aims to overcome these limitations by integrating optical microphones with deep learning techniques. Experimental validation demonstrates significant enhancements in listening efficacy for hearing aid users in such scenarios, paving the way for new research directions in speech signal sensing technology.
Future Tech | Biotechnology ＆ Medical careOur team has developed a hyaluronic acid-drug conjugation technology to create a polymer nanoparticle drug delivery system. It significantly enhances the grafting efficiency of hydrophobic drugs onto hyaluronic acid, reduces byproduct formation, and improves solubility. These hyaluronic acid conjugates, with targeted delivery and immune modulation properties, have been licensed and advanced to USFDA Phase II clinical trials, along with several preclinical drug and immune adjuvant developments.
Future Tech | Biotechnology ＆ Medical careOur team leverages three core technologies to develop a highly realistic, multifunctional dummy system for thermal ablation surgery simulation training. These technologies include (1) Biomimetic Dual-network Artificial Materials (BDAM). (2) Interactive Mock Human Circulatory System (IMHCS). (3) Embedded Soft Inductive Sensors (ESIS) technology. We have validated the feasibility of this system through four clinical case studies, demonstrating improved training effectiveness for novice surgeons.
Future Tech | Biotechnology ＆ Medical careThis invention relates to a new chemical compound of Isopropyl-D-glucopyranoside derivatives and its total synthesis to prepare the chemical compound. The invention also provides uses of the Isopropyl-D-glucopyranoside derivatives for promoting regeneration of injured brain neurons and retinal neurons. In addition, the Isopropyl-D-glucopyranoside derivatives can promote recovery motor function deficit .
Future Tech | Biotechnology ＆ Medical careNanoelectroporation technology efficiently produces dual-targeted, nucleic acid-enriched extracellular vesicles (EVs) for disease treatment. This innovative method utilizes proprietary nano-electroporation to create EVs enriched with therapeutic nucleic acids, targeting peptides, and antibody conjugation. These EVs show excellent tissue targeting and penetration, delivering large amounts of nucleic acid drugs and escaping endosomes for efficient cellular uptake and utilization.
Future Tech | Biotechnology ＆ Medical careTissue engineering (TE) and regenerative medicine aim to improve the quality of human life via fabricating functional scaffolds with tissue-specific physiology and anatomical resemblance that are able to replace, repair, or regenerate damaged tissues/organs, thereby restoring their essential functions. Conventional electrospinning technique (ES) can constructs ECM-mimicking nano/microfibrous scaffolds via electrical jet bending instabilities-driven random motion. Nevertheless, it hardly achieves 3D topographic scaffolds construction due to the complex jet-field interactions until our recent report on a novel "autopilot single jet (AJ)" phenomenon that gradually expands the fiber deposition area and thickness across given stationed-3D collectors conformally, resembling silkworm cocoon construction, as a result of the combination of rapid jet self-switching between two distinctive modes, namely microcantilever-like armed jet and whipping jet, and its exceptional 360⁰ self-3D field searching feature, which unprecedentedly produced functional organ-scale free-standing 3D topographic polycaprolactone (FDA-approved biocompatible and biodegradable PCL polymer) scaffolds, notably human face, female breast/nipple, and vascular graft shapes, with excellent shape memory, high porosity and stretchability. Conformal fiber deposition by AJ across the templates with higher level of complex geometries successfully achieved via manipulation of collector orientation to the writing tip, thus breaking similar electrostatic-affinity of AJ towards field-equivalent geometries, which, in turn, avoiding undue jet oscillations. The AJ process is also reproducible in horizontal setup, i.e., horizontal placement of writing tip and template, unaffected by gravity, which manifests its robustness. Thus, AJ-based "3D electrospinninde"monstrates striking potential to serve in broad spectrum of tissue engineering and regenerative medicine applications promised with high societal impact.
Future Tech | Biotechnology ＆ Medical careEstablish human gut ecosystem simulator for dynamically culturing gut microbiome. Probiotic extracellular vesicles (EV) are used as natural nanocarrier to target pathogen and deliver specific RNAs to treat infection. EV target different tissues after oral administration, effectively inhibiting C. difficile proliferation and virulence without affecting other gut microbiota. The method offers high safety, low cost, high yield, and net-zero emissions, demonstrating significant commercial potential.
Future Tech | Biotechnology ＆ Medical careMental illnesses cause accelerated brain aging as they progress. Professor Albert Yang＇s team discovered distinct degeneration trajectories in different brain regions and developed a method to precisely quantify degeneration at various ages and stages of mental illness. This technique, applied to schizophrenia, bipolar disorder, and major depressive disorder, establishes a platform for tracking personalized brain degeneration and is used in clinical services at Taipei Veterans General Hospital.
Future Tech | Biotechnology ＆ Medical careThis innovative medical technology for acute myocardial infarction (AMI) leverages two inventions: a light-activated nitric oxide (NO) nanomedicine and an optofluidic catheter. The catheter delivers light and nanomedicine, enabling localized and rapid NO generation near the infarction zone. We demonstrated treatment efficacy on a pig AMI model, showing significantly reduced myocardial necrosis and apoptosis, and improved ventricular function.
Future Tech | Biotechnology ＆ Medical careComing soon!
