An automated microfluidic system for detecting cholangiocarcinoma cells in bile for early diagnosis and prognosis
Technology Introduction:
The automated microfluidic system enables early cholangiocarcinoma diagnosis using 1 mL bile in 3 hours. Integrating centrifugal and "CAPTURE" module, it uses anti-EpCAM, octasaccharides, and aptamers for triplex cross-validation. An over-100-case clinical single-blind trial achieved 92% accuracy, 93% sensitivity, and 88% specificity. By detecting cancer cells in inflammation-only patients, this low-cost, compact desktop device offers immense commercialization potential and clinical value.
Industrial Applications:
To overcome imaging limits in early cholangiocarcinoma detection, we developed an automated microfluidic diagnostic system. An over-100-case single-blind trial achieved 92% accuracy, 93% sensitivity, and 88% specificity, successfully detecting cancer cells in patients previously diagnosed with severe inflammation. Using low-cost PDMS chips, this compact system delivers results in 3 hours. It is ideal for routine hospital health checks, offering immense commercial value for precision health.
National Tsing Hua University
National Tsing Hua University (NTHU), established in 1911 and located in Hsinchu, Taiwan, is one of the top research universities in the country. NTHU offers a wide range of programs in fields such as engineering, science, management, and humanities. The university is known for its strong emphasis on innovation, research excellence, and fostering global perspectives. With a commitment to academic rigor and interdisciplinary collaboration, NTHU plays a key role in advancing knowledge and technological development, contributing to both Taiwan’s growth and the global academic community.
Contact Information
Name：Yu-Jie, Huang
Tel：03-571-5131 #33769
Address：No. 101, Section 2, Kuang-Fu Road, Hsinchu City
