AAV-based Gene Therapy for Hereditary Hearing Loss
Technology Introduction:
Using high-inner-ear-tropism AAV vectors, this technology delivers therapeutic genes for Taiwan- and Asia-relevant hereditary hearing-loss genes, including SLC26A4 and PJVK. In mouse models, it improved auditory and balance functions while protecting hair cells and ganglion neurons, overcoming the limits of electronic devices that cannot restore biological hearing. It offers a one-time precision gene therapy platform for hereditary hearing loss.
Industrial Applications:
Current therapies for hereditary hearing loss rely on electronic devices and cannot correct the underlying pathology. This technology uses novel AAV vectors to precisely augment SLC26A4, common in Asian populations, and PJVK, associated with auditory neuropathy. Mouse studies show inner ear gene delivery that improves hearing and balance, supporting technology licensing and clinical translation.
Taipei Veterans General Hospital
As one of Taiwan's premier national medical centers and public hospitals, it was founded in 1958 and specializes in acute and critical care alongside pioneering medical research. It consistently ranks among the top hospitals in Taiwan in Newsweek’s World's Best Hospitals list.
Contact Information
Name：Nian-Ting Wu
Tel：02-2871-2121 #82046
Address：No.201, Sec. 2, Shipai Rd., Beitou District, Taipei City,Taiwan 112201, R.O.C.
