The manufacturing method of solid desiccant wheel was developed by Institute of Nuclear Energy Research (INER) to meet the need of low temperature dehumidification for Taiwan industries. Because of the production of solid desiccant wheel was not available in Taiwan the cost of dehumidification equipment was higher than other countries. In this work, the alumina was extracted from aluminum dross and applied as raw material to fabricate solid desiccant wheel by INER. The energy saving, environmentally friendly and cost effective could be reached through combining heat regeneration and solid desiccant wheel dehumidification apparatus.