The innovative device of the Baby Crib Spread Purifier combined an air purifier with transparent acrylic and polyvinylchloride shields to block the particulars and allergens transmission. The air purifier was made of a P100 high efficiency particulate air (HEPA) filter and centrifugal fan. In this way, it can filter out airborne particles from the surrounding air, preventing from droplet infection and maintain the air quality. As for the transparent shield, caregivers can lift it, hold up the infant and monitor immediately.