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Development of novel cannabinoid CB1receptor antagonists with high oral absorption and no central adverse effects for the treatment of cardiovascular diseases

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Development of novel cannabinoid CB1receptor antagonists with high oral absorption and no central adverse effects for the treatment of cardiovascular diseases

Using high-throughput screening, we discovered that soybean isoflavone genistein (GEN) is a novel CB1 receptor antagonist that does not cross the blood-brain barrier, thereby avoiding CNS effects and psychiatric side effects. We further enhanced the water solubility and oral bioavailability of GEN through microbial fermentation. This strategy has been patented and can be used to treat cardiovascular diseases and has therapeutic potential for other diseases related to abnormal CB1 activation.

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  • Pavilion:Future Tech Bio-tech, New Drugs & Medical Devices FN13

  • Affiliated Ministry:National Science and Technology Council

  • Application Field:Biotechnology & Medical care

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  • Technology maturity:Prototype

  • Exhibiting purpose:Display of scientific results

  • Trading preferences:Negotiate by self

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