Development of an Implantable Bioelectronic Platform for the Peripheral Neuromuscular System Regeneration

Inquiry

Peripheral nerve electrical stimulation is currently known to promote peri
pheral nerve nerve regeneration, but its benefits for distal muscles and th
e innervated neuromuscular junction remain unclear. In our published coll
aborative research with researchers in University of California, Los Angeles
(UCLA), it was confirmed that providing nerve electrical stimulation to the
distal end of the damaged nerve can enhance the regeneration of the neu
romuscular junction and restore functional muscle recoveries. Based on th
ese innovative findings, our research team further optimized and swiped v
arious parameters of electrical stimulation to identify a set of optimal para
meters that promote the maintenance of the neuromuscular junction and
acetylcholine recycling, leading to better muscle fiber regeneration and i
mproved functional recovery. This invention provides an optimal combina
tion of nerve electrical stimulation parameters for the peripheral nervous
and muscular systems, offering an enhanced regenerative mechanism and
reduced degeneration at the neuromuscular junction for peripheral nerve
and muscle damage. By integrating the optimized parameters with curren
t preliminary validated implantable wireless electrical stimulation platfor
m of this invention, it enables superior structural and functional recovery
of the damaged neuromuscular system. In the future, this invention holds
potential benefits not only for peripheral nerve injuries but also for

National Cheng Kung University

Due to NCKU’s rapid development, the R&D Committee has become increasingly important. In order to meet the needs of NCKU's academic research planning, integration, industry cooperation and academic cooperation, it has become an independent operating unit for practical functions. Therefore, in the 5th University Council of the 1994 academic year, the R&D Committee was renamed the Office Of R&D(ORD) after the amendment of Article 8 of NCKU’s organizational regulations. NCKU Regulations Governing the Establishment of the Office of Research and Development were approved in the 7th University Council of the same academic year. In addition to the original three divisions, the instrumentation equipment center was established for integration and planning of NCKU’s relevant instrumentation and equipment, bringing further into play the overall function of ORD, which will be more beneficial to NCKU’s teachers and students. In June 2006, the Office of International Academic was established. The Academic Cooperation Division of ORD Department was converted into the International Cooperation Division and shifted to the Office of International Academic. Original URL: History and Vision https://en.ord.ncku.edu.tw/article-history.html The copyright belongs to the author. For commercial reprints, please contact the author for authorization, and for non-commercial reprints, please indicate the source.