Bioelectronic medicine is utilizing microelectrodes to record nerve signals
and employs electrical stimulation to control neuron activity. However, im
plantable medical electronics easily cause negative effects such as damag
e to the local soft tissue. Accordingly, a novel technology combining the p
rinciples of electronic aids and regenerative medicine is developed. The te
chnology involves the creation of a degradable implantable soft self-adhe
sive electronic patch, which integrates high-resolution electrical stimulati
on, signal sensing, and cell regeneration therapy. The technology begins
with material engineering, where collagen combined with silk protein and
enzymes to form a hydrogel as an electronic substrate. This hydrogel perf
ectly matches the tissue, exhibits self-adhesiveness, adjustable degradability, and can also accommodate stem cells. For electronic circuits, a highly c
onductive dual-structure hydrogel is created by doping collagen with con
ductive polymers and graphene. This conductive material possesses phot
oresist properties and can be rapidly patterned into various electrode micr
ostructures. By incorporating a degradable polylactic acid as an insulating
layer, the technology achieves precise treatment, mass production, and a c
ost-effective and straightforward water-based adhesive electronic packagi
ng process. The use of practical enzymes induces viscosity, enabling one-s
tep transfer printing to combine all device stacks, forming a full hydrogel
degradable microelectrode array patch.The jelly-like electronic patch not
only provides adhesion and controllable degradation but also allows for
micron-level nerve signal recording and electrical stimulation. For nerve in
juries, the patch can serve dual roles as both medical electronics and nerv
e conduits. Importantly, it can be left in the original tissue and fused with i
t without requiring surgical removal, ultimately accelerating damage heali
ng.