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Application of a novel nucleic acid structure immune activation composition as adjuvant for nasal spray vaccines

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Application of a novel nucleic acid structure immune activation composition as adjuvant for nasal spray vaccines

The combination of CpG-2722 and 2’3’-c-di-AM(PS)2 exhibited a cooperative adjuvant effect for SARS-CoV-2 RBD vaccines and a favorable safety profile in the nasal cavities of mice. CpG-2722/cyclic dinucleotide combinations enhanced the performance of nasal H7 influenza vaccines. Nasal administration of these combination-adjuvanted shingles vaccines elicited a superior vaccine response compared to intramuscularly injected Shingrix, indicating the superior adjuvant activity of these combinations.

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  • Pavilion:Future Tech Healthy Taiwan Theme Area FM07

  • Affiliated Ministry:Ministry of Health and Welfare

  • Application Field:Biotechnology & Medical care

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  • Technology maturity:Experiment stage

  • Exhibiting purpose:Display of scientific results

  • Trading preferences:Negotiate by self

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