Application of a novel nucleic acid structure immune activation composition as adjuvant for nasal spray vaccines
The combination of CpG-2722 and 2’3’-c-di-AM(PS)2 exhibited a cooperative adjuvant effect for SARS-CoV-2 RBD vaccines and a favorable safety profile in the nasal cavities of mice. CpG-2722/cyclic dinucleotide combinations enhanced the performance of nasal H7 influenza vaccines. Nasal administration of these combination-adjuvanted shingles vaccines elicited a superior vaccine response compared to intramuscularly injected Shingrix, indicating the superior adjuvant activity of these combinations.
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Demonstration of a Superior Deep-UV Surface-Enhanced Resonance Ram an Scattering (SERRS) Substrate and Single-Base Mutation Detection in O ligonucleotides
Development of novel cannabinoid CB1receptor antagonists with high oral absorption and no central adverse effects for the treatment of cardiovascular diseases
Novel cancer immunotherapeutic agent targeting tumor and tumor immune microenvironment for the treatment of triple negative breast cancer
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