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Administration with recombinant fragment of human SP-D (rfhSP-D) in t he diagnosis and treatment for chronic obstructive pulmonary disease

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Administration with recombinant fragment of human SP-D (rfhSP-D) in t he diagnosis and treatment for chronic obstructive pulmonary disease

The surfactant protein D (SP-D) is produced by type II alveolar cells and se
rves as an antimicrobial agent as well as to prevent inflammation. Our pre
vious study examined single nucleotide polymorphisms in the SP-D gene i
n Taiwanese COPD patients. We found that SP-D gene variants were relate
d to COPD clinical manifestations, severity and prognosis. SP-D levels wer
e significantly associated with COPD airflow obstruction. We found haplot
ype G-G-C-C-A associated with lower COPD risk. COPD patients with hapl
otype G-G-C-C-A had lower serum SP-D levels, higher rates of positive res
ponse to bronchodilator treatment, more improvement of forced expirato
ry volume in 1 s in yearly follow-up and better 3-year survival rate than C
OPD patients with non G-G-C-C-A haplotype. It appears that SP-D haploty
pe can be used as a prognostic factor in Chinese COPD patients. Our invention identifies SP-D gene variants that are predictive of COPD occurrence
and prognosis, and has gained USA patent status. COPD, including chroni
c bronchitis and emphysema, is Taiwan's seventh leading cause of death
and America's third leading cause. Our innovation is that we are the first
team in the world to apply fragment of recombinant human lung surfacta
nt protein D (rfhSP-D) to treat ozone and cigarette-exposed mice model o
f COPD. Exogenous rfhSP-D prevented the formation of oxidized low-den
sity lipoprotein-induced foamy macrophage in vitro and reversed the airw
ay inflammation and emphysematous changes caused by oxidative stress
and CS exposure in vivo. SP-D upregulated the expression of genes involv
ed in countering oxidative stress and lipid metabolism perturbations indu
ced by CS and OxLDL in bone marrow-derived macrophages. We demonst
rate that SP-D plays a crucial role in maintaining the lipid homeostasis of
dysfunctional alveol

China Medical University

Currently, there are nine colleges, including the College of Medicine, College of Dentistry, College of Pharmacy, College of Traditional Chinese Medicine, College of Public Health, College of Health Care, College of Life Sciences, College of Humanities and Technology, and College of Medical Engineering, including 23 bachelor's programs, 34 master's programs, 20 doctoral programs, and teaching, research, and medical units such as the Taichung Affiliated Hospital, Beigang Affiliated Hospital, Hsinchu Affiliated Hospital, Children's Hospital, and Tainan Municipal Annan Hospital (commissioned to be built and operated by China Medical University). The university is well-equipped with various research and medical facilities, of which about 70% are related to Chinese and Western medicine. It provides the most complete curriculum in the country with the characteristics of the integration of Chinese and Western medicine, cultivates medical, nursing, pharmaceutical, and technical professionals with the characteristics of the integration of Chinese and Western medicine, and develops the three most Chinese medicine-based fields, including the development of Chinese medicine resources, the research and development of Chinese medicine health foods and anti-disease drugs, and the theory and application of Chinese medicine (including acupuncture). After nearly half a century of intensive cultivation, the university has developed into an excellent institution of higher education in the country and even the world with the most Chinese and Western medicine-based integration characteristics, and has gradually implemented the scientification, modernization, and internationalization of Chinese medicine, as well as pioneered the emerging medicine that combines Chinese and Western medicine.

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  • Address:91,Hsueh-Shih Road, Taichung,404, Taiwan,Republic of China

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  • Pavilion:Future Tech Bio-tech, New Drugs & Medical Devices FF08

  • Affiliated Ministry:National Science and Technology Council

  • Application Field:Biotechnology & Medical care

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  • Technology maturity:Experiment stage

  • Exhibiting purpose:Display of scientific results

  • Trading preferences:Negotiate by self

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