Bioinspired iKNOBEADS as Ancillary Materials for Next-Generation Cell Immunotherapy
Cell immunotherapy has become an emerging cancer therapy. Take CAR-T as an example. T-cells in patients’ blood must undergo genetic modification and expansion in vitro before being reinfused. This standard process takes 10 to 12 days. In the human body, dendritic cells with irregular protrusion activate T-cells. Under the bionic concept, ITRI developed the world’s first micron-sized magnetic beads with dendritic-like configurations named iKNOBEADS. Its unique structure enhances the interaction between magnetic beads and T-cells, leading to higher T-cell expansion efficiency, better quality, and a reduced 7-day manufacturing time. iKNOBEADS can also potentially be applied to various cellular immunotherapies such as γδT, NK, and TIL. iKNOBEADS are available in GMP-grade quality and have already been proved by domestic and international research and studies.
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ITRI is a world-leading applied technology research institute with more than 6,000 outstanding employees. Its mission is to drive industrial development, create economic value, and enhance social well-being through technology R&D. Founded in 1973, it pioneered in IC development and started to nurture new tech ventures and deliver its R&D results to industries. ITRI has set up and incubated companies such as TSMC, UMC, Taiwan Mask Corp., Epistar Corp., Mirle Automation Corp., and Taiwan Biomaterial Co. ITRI is dedicated to creating new value and identifying emerging demands for partners while facing global challenges and opportunities, such as urbanization, aging societies, new production and consumption patterns, climate change caused by global warming, and a post-COVID-19 era.
Name：Cheng-Tai Chen
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Address：No. 321, Sec. 2, Guangfu Rd., East Dist., Hsinchu City 300044, Taiwan (R.O.C.)
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