Method of delivering drugs facilitated by microbubbles through indirect mechanical oscillation wave
A method of delivering drugs to the inner ear facilitated by microbubble, including mixing a microbubble composition and a drug into a microbubble-drug mixture, applying the microbubble-drug mixture to middle ear cavity, and placing a mechanical oscillation wave source in the external ear canal or cranium located behind the ear. The mechanical waves generated by the mechanical oscillation wave source penetrate through the tympanum or cranium and indirectly induce the cavitation with the microbubbles in the middle ear cavity. The permeability of the round window membrane thus increased and facilitated the drug penetrating the inner ear through the round window membrane. Therefore, the mechanical oscillation wave source could be indirectly applied to the microbubbles and induced the cavitation effect in a non-invasive way.
The National Defense Medical University (NDMU) is the military medical university of Taiwan’s armed forces, under the jurisdiction of the Ministry of National Defense Medical Bureau. Located in Neihu, Taipei, it forms the National Defense Medical Center together with its affiliated teaching hospital, Tri-Service General Hospital, and other military medical institutions. NDMU is a key contributor to medical, food, and pharmaceutical research in Taiwan, and has assisted in establishing numerous medical and educational institutions, including veterans’ hospitals, military hospitals, National Yang-Ming Medical College (now National Yang Ming Chiao Tung University Taipei Yang-Ming Campus), National Taiwan University’s School of Nursing, NTU Hospital Department of Anesthesiology, and Jingde Pharmaceutical Factory.
Name：Hang-Kang Chen
Phone：
Address：No.161, Minquan E. Rd., Sec. 6, Neihu, Taipei, 11490, Taiwan
I797392
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