We aim to construct in vitro multi-organ models (e.g., liver/kidney or liver/kidney/tumor), and to simulate the micro-environments interaction by using the "multi-organ array composed of assemblable organ chip bricks". It can be applied to drug metabolism, safety, and toxicity testing related to liver and kidney organs, as well as new drugs development in animal experiments. Therefore, it is expected to reduce animal expenditure in the drug development by over 50%.