Technology Introduction:
The half-maximal inhibitory concentration (IC₅₀) is a key pharmacological parameter for quantifying drug efficacy. We developed a label-free, contrast-enhanced surface plasmon resonance imaging technique to assess drug-induced cytotoxicity in cells. Compared to conventional assays such as cell proliferation kits and viability fluorescent staining, our platform yields highly consistent results. It enables accurate IC₅₀ measurement with the advantages of high throughput and label-free detection.
Industry Applicability:
A novel surface plasmon resonance sensing platform integrating patented nanoplasmonic chips with contrast-enhanced imaging technology offers label-free detection with high sensitivity and low cost. This technology is broadly applicable in the biomedical field, providing high-throughput and accurate evaluation of drug efficacy with strong market potential. The platform is also well-suited for applications such as molecular interaction analysis, pollutant monitoring, and food safety testing.