Targeted extracellular vesicle-based therapeutic platform: A nanocarrier for nucleic acid and chemotherapeutic drug delivery
Technology Introduction:
1. Developed Troy Exo, an engineered HEK293T-derived EV with αHLA-G nanobody for targeting.
2. Established GMP-grade cell bank and 100L-scale EV production with 65% αHLA-G expression.
3. Completed BioD, PK, and GLP toxicity studies showing excellent safety and tumor accumulation.
4. Dox-loaded EVs enhanced breast cancer killing by 4× with reduced cardiotoxicity.
5. miR-loaded EVs improved GBM therapy, increasing drug response by 2.3×.
6. Received FDA IND approval and accepted by Nat. Commun.
Industry Applicability:
Troy Exo is an engineered exosome platform featuring an αHLA-G nanobody, offering high targeting specificity, low immunogenicity, and excellent in vivo stability. It enables precise delivery of drugs and nucleic acids across biological barriers. With scalable GMP manufacturing up to 100L and strong IP protection, it supports multi-indication development, overcoming key limitations of synthetic nanocarriers and offering a next-generation targeted delivery solution.
Currently, there are nine colleges, including the College of Medicine, College of Dentistry, College of Pharmacy, College of Traditional Chinese Medicine, College of Public Health, College of Health Care, College of Life Sciences, College of Humanities and Technology, and College of Medical Engineering, including 23 bachelor's programs, 34 master's programs, 20 doctoral programs, and teaching, research, and medical units such as the Taichung Affiliated Hospital, Beigang Affiliated Hospital, Hsinchu Affiliated Hospital, Children's Hospital, and Tainan Municipal Annan Hospital (commissioned to be built and operated by China Medical University). The university is well-equipped with various research and medical facilities, of which about 70% are related to Chinese and Western medicine. It provides the most complete curriculum in the country with the characteristics of the integration of Chinese and Western medicine, cultivates medical, nursing, pharmaceutical, and technical professionals with the characteristics of the integration of Chinese and Western medicine, and develops the three most Chinese medicine-based fields, including the development of Chinese medicine resources, the research and development of Chinese medicine health foods and anti-disease drugs, and the theory and application of Chinese medicine (including acupuncture). After nearly half a century of intensive cultivation, the university has developed into an excellent institution of higher education in the country and even the world with the most Chinese and Western medicine-based integration characteristics, and has gradually implemented the scientification, modernization, and internationalization of Chinese medicine, as well as pioneered the emerging medicine that combines Chinese and Western medicine.
Name:
Phone:04-2296-7979 #3705
Address:91,Hsueh-Shih Road, Taichung,404, Taiwan,Republic of China
I836766
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