The Biodata Platform, an interministerial sustainable platform for Taiwan’s health big data, has been setup based on the 4-year Health Big Data project since 2021. The platform’s vision is to integrate the health data in Taiwan as an international benchmark for data-driven translational research and clinical practice for precision health. For project implementation, we set up the project office and established collaboration among Ministry of Health and Welfare (MOHW), Ministry of Economic Affairs (MOEA), and National Science and Technology Council (NSTC). The anticipated benefits of this platform include health big data infrastructure establishment, regulatory environment construction for using RWD/RWE in supporting decision making, biomedical translational research development, and biomedical industry innovation promotion. The platform involves (1) disease-specific databases which focused on cancer, infectious diseases, and cardiovascular diseases. In addition, the cross-ministerial mechanisms of data link and a single-entry portal will be set up. (2) To develop the RWD/RWE regulatory guidance and health technology assessment (HTA). (3) Artificial intelligence (AI) and the computing power of big data are utilized with biomedical databases to develop novel biomarkers and assessment models for disease risk prediction, diagnosis, and treatment. The platform also focuses on industry collaboration and innovation by establishing Public-Private Partnerships (PPP) alliance. Through the alliance and the coordinated operation mechanism to link the industry, government, and medical researchers. Hence, to further enhance the sustainable value of public health and well-being.