Fast Cancer Screening and Prognosis Assessment and Prediction of Treatment Response in Chronic Kidney Disease by Using Synchrotron Infrared Microscopy
"Infrared wax physisorption kinetics (iR-WPK) provides a glyco-histopathological imaging analysis for examining tissue sections, which utilizes n-alkanes (n-CnH2n＋2) with carbon number (CN) from 20 to 34 and beeswax as glycan adsorbents for targeting similar longitudinal length of glycans of glycoconjugates anchoring in the cell surface.
It is an in-situ non-destructive method of examining tissue sections for cancer screening and prognosis prediction for chronic kidney disease by profiling aberrant glycans covalently-attached to both glycoconjugates anchored in tissue sections.
It can screen ten cancers including colon cancer, breast cancer, ovary cancer, cervical cancer, oral cavity cancer, gastric cancer, skin cancer, prostate cancer, intestinal neuroendocrine tumor and brain cancer.1. Infrared wax physisorption kinetics (iR-WPK) can provide an in-situ non-destructive glyco-histopathological imaging analysis at the spatial resolution of 10 × 10 m2 for cancer screening and prognosis prediction for chronic kidney disease diagnosis by detecting the distribution of the population ratio of aberrant to regular glycans respectively attached to glycoconjugates anchored in the cell surface and immune complex deposited onto glomerulus.
2. iR-WPK is useful for screening ten cancers, including colon cancer, breast cancer, ovary cancer, cervical cancer, oral cavity cancer, gastric cancer, skin cancer, prostate cancer, intestinal neuroendocrine tumor and brain cancer. Single detection at room temperature (28°C) takes only 6~15 minutes.1. Infrared wax physisorption kinetics (iR-WPK) can provide an in-situ non-destructive glyco-histopathological imaging analysis at the spatial resolution of 10 × 10 m2 for cancer screening and prognosis prediction for chronic kidney disease diagnosis by detecting the distribution of the population ratio of aberrant to regular glycans respectively attached to glycoconjugates anchored in the cell surface and immune complex deposited onto glomerulus.
2. iR-WPK is useful for screening ten cancers including colon cancer, breast cancer, ovary cancer, cervical cancer, oral cavity cancer, gastric cancer, skin cancer, prostate cancer, intestinal neuroendocrine tumor and brain cancer. Single detection at room temperature (28°C) takes only 6~15 minutes."
NSRRC, the biggest large-scale shared research facility in Taiwan, currently operates two accelerators, the Taiwan Light Source (TLS) and the Taiwan Photon Source (TPS). TLS, of beam energy 1.5 GeV and circumference 120 meters, is the first third-generation synchrotron light source facility in Asia and the third globally. It has opened to users since October, 1993. The best optimized energy range of synchrotron light from TLS is between vacuum ultraviolet light and soft X-rays. The TPS, of circumference 518.4 meters, is one of the brightest synchrotron light sources in the world. It began its operation in September, 2016. To meet the demands from modern technologies and pioneer sciences for higher-brightness light beams, such as biomedicine and nanoscience, it is equipped with a low-emittance synchrotron storage ring and booster synchrotron producing a beam of energy 3 GeV. It generates X-rays in the higher energy range from soft X-rays to hard X-rays, and has a capacity of more than 40 beamlines. In addition, NSRRC built and operates two hard X-ray Taiwanese beamlines at SPring-8, Japan, as well as a cold neutron triple-axis spectrometer at the Australian Nuclear Science and Technology Organisation (ANSTO), under the international collaboration agreements. Scientists from around the world can access NSRRC’s facilities to explore the properties of materials in a wide range of disciplines through a competitive proposal process. Every year, over 2,000 users use NSRRC’s experimental facilities, which not only enable basic research, but also facilitate high-tech innovation. NSRRC possesses one of the most advanced synchrotron facilities in the world and its pioneering capabilities keep Taiwan at the forefront of scientific research.
Enhancing Anodization of Semiconductor Materials Technology with Waf er Bonding Transforming Interface Function
Highly Efficient Fabrication and Applications of Bioinspired Flexible Photonic Crystals by Trapping of Structural Coloration
Towards Automatic Hyperspectral Imaging via the Combination of Sample Navigation MappingLaser Scanning Spectral Microscopy
Remote-control robot agent for epidemic prevention robot using the combination of virtual reality and inertial measurement unit based posture detector
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