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Multimodal nonlinear optical microscopy platform for the identification of artificial bone materials

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Multimodal nonlinear optical microscopy platform for the identification of artificial bone materials

This technique uses multimodal nonlinear optical microscopy with the image contrast of second harmonic generation (SHG) and coherent anti-Stokes Raman scattering (CARS). By analyzing the nonlinear signals on images, it can be used to characterize and quantify the structural variation in the collagen scaffolds processed with different crosslinking methods. The correlation between signals and mechanical properties can then be derived. Additionally, comparative analysis of these two signals can be used to monitor the structural (triple-helix) change of collagen molecules during the crosslinking processes.
This technique is able to quantitatively analyze the structure of synthetic materials of collagen, which can be applied to the quality control system in the medical material industry. Automated inspections in the semiconductor industry can also be achieved by the nonlinear signals produced from laser-device defect interactions. In the medical industry, early diagnosis of diseases and nonlinear endomicroscopy are the existing applications of this technique. In the future, we will use new algorithms to establish training models for bioengineered materials or diseases, promoting AI in medicine and personalized precision health.

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https://tievirtual.twtm.com.tw/iframe/fb192ac7-1979-4355-b2a3-09d40d2061e4?group=23bfb1fa-dd5b-4836-81a1-4a1809b1bae5&lang=en

China Medical University

Currently, there are nine colleges, including the College of Medicine, College of Dentistry, College of Pharmacy, College of Traditional Chinese Medicine, College of Public Health, College of Health Care, College of Life Sciences, College of Humanities and Technology, and College of Medical Engineering, including 23 bachelor's programs, 34 master's programs, 20 doctoral programs, and teaching, research, and medical units such as the Taichung Affiliated Hospital, Beigang Affiliated Hospital, Hsinchu Affiliated Hospital, Children's Hospital, and Tainan Municipal Annan Hospital (commissioned to be built and operated by China Medical University). The university is well-equipped with various research and medical facilities, of which about 70% are related to Chinese and Western medicine. It provides the most complete curriculum in the country with the characteristics of the integration of Chinese and Western medicine, cultivates medical, nursing, pharmaceutical, and technical professionals with the characteristics of the integration of Chinese and Western medicine, and develops the three most Chinese medicine-based fields, including the development of Chinese medicine resources, the research and development of Chinese medicine health foods and anti-disease drugs, and the theory and application of Chinese medicine (including acupuncture). After nearly half a century of intensive cultivation, the university has developed into an excellent institution of higher education in the country and even the world with the most Chinese and Western medicine-based integration characteristics, and has gradually implemented the scientification, modernization, and internationalization of Chinese medicine, as well as pioneered the emerging medicine that combines Chinese and Western medicine.

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  • Name:Zhuo Guan-Yu

  • Phone:04-2205-3366分機6508

  • Address:台中市北區學士路91號

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  • Pavilion:Future Tech Semiconductor block

  • Affiliated Ministry:National Science and Technology Council

  • Application Field:Electronics & Optoelectronics

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  • Technology maturity:Experiment stage

  • Exhibiting purpose:Product promotion、Display of scientific results

  • Trading preferences:Exclusive license/assignment、Technical license/cooperation、Negotiate by self

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