Super resolution ultrasound vector blood flow imaging

Inquiry

Most lesions change the characteristics of blood vessels in normal tissues.
For example, malignant tumors often proliferate blood vessels, and arthritis is also accompanied by inflammatory reactions such as new blood vesse
ls. Therefore, it has clinical significance to provide effective and early dete
ction of neovascularization. Although the Ultrasound Localization Microsc
opy (ULM) is available for high resolution angiography, the limitation of U
LM is that it must inject ultrasonic contrast agents into blood vessels, and
because microbubbles must be tracked, therefore, the time resolution is v
ery low, coupled with the limitation of the clinical use of contrast agents, t
his technique is not yet widely used in clinical applications. Compared wit
h ULM technology, the resolution of clinical ultrasonic blood flow images
can reach 1 mm. It is still a big challenge for the blood flow measurement
of proliferative microcirculation (diameter < 100 μm). This limitation is att
ributed to two reasons: 1. Insufficient resolution of current clinical ultraso
und imaging and 2. Difficulty in estimating the Doppler angle of microcirc
ulatory vessels. In order to break through the resolution of clinical ultraso
nic imaging system, this technology has developed super resolution ultras
ound vector flow imaging, which can measure the minimum vessel diamet
er without using ultrasonic contrast agent. It can reach 20 μm and the hig
hest time resolution can reach 1 kHz, which can provide super resolution b
lood flow images for clinical diagnosis. In addition, when using ultrasonic
Doppler technology to measure blood flow, because it is difficult to estim
ate the Doppler angle of microcirculatory vessels, there is a huge error in t
he correct measurement of blood flow velocity. At the same time, this tech
nology has developed vector Doppler radiography, which can estimate ve
ctor blood flow through multi-angle plane waves, and can accurately mea
sure microcirculatory blood flow velocity

National Cheng Kung University

Due to NCKU’s rapid development, the R&D Committee has become increasingly important. In order to meet the needs of NCKU's academic research planning, integration, industry cooperation and academic cooperation, it has become an independent operating unit for practical functions. Therefore, in the 5th University Council of the 1994 academic year, the R&D Committee was renamed the Office Of R&D(ORD) after the amendment of Article 8 of NCKU’s organizational regulations. NCKU Regulations Governing the Establishment of the Office of Research and Development were approved in the 7th University Council of the same academic year. In addition to the original three divisions, the instrumentation equipment center was established for integration and planning of NCKU’s relevant instrumentation and equipment, bringing further into play the overall function of ORD, which will be more beneficial to NCKU’s teachers and students. In June 2006, the Office of International Academic was established. The Academic Cooperation Division of ORD Department was converted into the International Cooperation Division and shifted to the Office of International Academic. Original URL: History and Vision https://en.ord.ncku.edu.tw/article-history.html The copyright belongs to the author. For commercial reprints, please contact the author for authorization, and for non-commercial reprints, please indicate the source.