We developed a three-dimensional plasmonic hot-spot rich (3D-PHS) nan
ochip, which was constructed based on a random crossed-wire silver nano
wire woodpile structure. 3D-PHS can provide 3D LSPR and hot spots, whic
h can integrate the signal processing software to become a CSDP system t
hat can be applied to any Raman instrument. Especially, we have also deve
loped a portable spectrometer to fit CSDP and eventually it becomes a po
werful rapid screening detection system. At this stage, CSDP has been suc
cessfully applied to two items: agriculture (pesticides, orchid virus) and bi

omedical testing (drugs, bilirubin, bacteria, cancer cells, antibodies and an
tigens, and coronaviruses). Among them, pesticides have reached the far
m test; bilirubin has successfully cooperated with NTU Hospital and clinica
l data collection. Covid-19 virus and antibody information has also been e
stablished. Such biosensing technology can be used by healthcare units fo
r effective Point of Care Testing (POCT).