Our technology is dedicated to developing the ingestible batteries to supply a safer power source to medical devices. The principle of power generation is to utilize the hydrogels consisting of different salt concentration gradients and an ion-selective membrane placed between them so that the anions and cations can flow into the system to be distributed at both ends of the hydrogels and then generate the electric current. Furthermore, a nanogenerator (TENG) is employed to charge the battery. This technique can be used to apply voltage to the bacteria and destroying them after turning on the power. In the future, this technique can be used for destroying pathogenic bacteria present in the gut, or for providing a harmless power source for electrical stimulation of the digestive tractOur technology is very unique and pioneering. We developed an ingestible battery composed of hydrogels with different salinities and ion-selective membranes placed between them. The ions migrate from high-salinity to low-salinity hydrogel; ion-selective membrane enhances the flow of ions to generate electricity. The constituent materials (agarose & gellan gum) are edible, so they are harmless to humans, unlike conventional batteries. Due to its high biocompatibility, non-toxicity and safety to the human body, it can be used as a power source for wide applications. Besides, it becomes fascinating when combined with a triboelectric nanogenerator (TENG) converting kinetic energy into electrical energy for battery charging. Also, it is promising for tackling pathogenic bacteria, e.g. E. coli.Our technology can be used in many industries, e.g., for energy, medical equipment, clinical dentistry, etc. Battery-operated devices pose a high risk of accidental swallowing of batteries (e.g., button batteries) especially by children, resulting in injuries. The ideal power source should be highly biocompatible & non-toxic. Our technology is promising for being ingestible and safer. Even if this battery leaks electrolyte in the body accidentally, it won’t cause any harm. Besides, it promotes sustainable environmental protection as constituent materials offer high biodegradability. It can be combined with a nanogenerator (TENG) for charging for re-use. We utilized our strategy to kill or inhibit E. coli. In the future, it can be used to kill bacteria in oral cavity to prevent tooth decay.