The present invention discloses a vascular bone organoid and its compression perfusion fabricator system. The compression-perfusion fabricator system includes a compression device, a culture tank, a perfusion device, and a microcomputer driver. The compression device and the perfusion device are controlled and adjusted through the microcomputer driver to provide dynamic mechanical compression and perfusion stimulation simultaneously. The system simulates the dynamic microenvironment within the human body. The present invention further utilizes 3D bioprinting technology to manufacture a vascular bone organoid, which is cultured in the compression-perfusion fabricator system, to mimic the growth of bone and vascular endothelial cells within the normal dynamic physiological environment of the bone marrow cavity.
The National Defense Medical University (NDMU) is the military medical university of Taiwan’s armed forces, under the jurisdiction of the Ministry of National Defense Medical Bureau. Located in Neihu, Taipei, it forms the National Defense Medical Center together with its affiliated teaching hospital, Tri-Service General Hospital, and other military medical institutions. NDMU is a key contributor to medical, food, and pharmaceutical research in Taiwan, and has assisted in establishing numerous medical and educational institutions, including veterans’ hospitals, military hospitals, National Yang-Ming Medical College (now National Yang Ming Chiao Tung University Taipei Yang-Ming Campus), National Taiwan University’s School of Nursing, NTU Hospital Department of Anesthesiology, and Jingde Pharmaceutical Factory.
Name：Jia-Fwu Shyu
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Address：No.161, Minquan E. Rd., Sec. 6, Neihu, Taipei, 11490, Taiwan
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