Egg yolk immunoglobulin (IgY) has the advantage of producing large amounts of high-specificity antibodies quickly and at low cost in the yolk. Let IgY become a new choice for preventing infection and detecting. The invention is relative to the composition of immunoglobulin IgY in the therapeutic/prevention of norovirus infection. The claim of this application including 1. the anti-norovirus Immunoglobulin IgY derived from chicken yolk, and the acceptable compositions. 2. The methodology for the preparation of this composition. 3. The purpose of this composition for treatment and/or prevention of norovirus infection.